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chemical structure of propafenone
Propafenone (marque Rythmol®) occurs as class Ic anti-arrhythmic medication. These are utilized in the professional assistance of atrial and ventricular arrhythmias.
It works by deceleration a inflow of sodium ions into the cardiac muscle cells, stimulating the decrease within excitablity of the cells.
Propafenone is metabolized primarily in the liver. Because of its short half-life, it requires dosing 2 or threefold daily to maintain steadily blood levels. A long-long-run safety of propafenone is unknown. Because these are structurally similar to an additional unsafe anti-arrhythmic medicine, flecainide, caution should be exercised around its utilize. Flecainide has been shown to increase a occurrence of unsafe arrhythmias.
Side results attributed to propafenone include hypersensitivity responses, lupus-like syndrome, agranulocytopenia, CNS disturbances such as vertigo, lightheadedness, G.I personally. upset, metal taste & bronchospasm.
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